4.1 An undesirable effect of a drug that occurs at therapeutic doses and can be predicted from its pharmacological actions is called:
A. Side effect
B. Toxic effect
C. Allergic reaction
D. Idiosyncrasy
4.2 Which of the following is a type B (unpredictable) adverse drug reaction:
A. Side effect
B. Toxic effect
C. Idiosyncrasy
D. Physical dependence
4.3 The side effect of a drug which has been used as a therapeutic effect in another condition is:
A. Constipation caused by codeine
B. Cough caused by captopril
C. Uterine stimulation caused by quinine
D. Diarrhoea caused by ampicillin
4.4 A ‘toxic effect’ differs from a ‘side effect’ in that:
A. It is not a pharmacological effect of the drug
B. It is a more intense pharmacological effect that occurs at high dose or after prolonged
medication
C. It must involve drug induced cellular injury
D. It involves host defence mechanisms
4.5 The following statement is true in relation to ‘drug toxicity’ and ‘poisoning’:
A. The two terms are synonymous
B. When a toxic effect requires specific treatment, it is called poisoning
C. A toxic effect which endangers life by markedly affecting vital functions is called poisoning
D. Toxicity is caused by drugs while poisoning is caused by other harmful chemicals
4.6 Use of an emetic to remove the ingested poison is contraindicated in following poisonings except that by:
A. Strychnine
B. Caustic soda
C. Ferrous sulfate
D. Kerosene
4.7 Which of the following is an idiosyncratic adverse drug reaction:
A. Muscle dystonia caused by triflupromazine
B. Insomnia after taking pentobarbitone
C. Precipitation of asthma by morphine
D. Gum hyperplasia caused by phenytoin
4.8 An immunologically mediated reaction to a drug producing stereotyped symptoms unrelated to its pharmacodynamic actions is:
A. Hypersensitivity
B. Supersensitivity
C. Intolerance
D. Idiosyncrasy
4.9 Drugs producing allergic reactions generally act as:
A. Complete antigens
B. Haptenes
C. Antibodies
D. Mediators
4.10 The following allergic drug reaction is caused by circulating antibodies:
A. Serum sickness
B. Anaphylactic shock
C. Systemic lupus erythematosus
D. Angioedema
4.11 Which of the following is the only life saving measure in case of anaphylactic shock:
A. Intravenous hydrocortisone hemisuccinate
B. Intravenous chlorpheniramine maleate
C. Intramuscular adrenaline hydrochloride
D. Intravenous glucose-saline
4.12 The type II, type III and type IV hypersensitivity reactions can be suppressed by:
A. Adrenaline
B. Antihistaminics
C. Corticosteroids
D. Sod. cromoglycate
4.13 The most appropriate route of administration for adrenaline in a case of anaphylactic shock is:
A. Intracardiac
B. Intravenous
C. Intramuscular
D. Subcutaneous
4.14 Intradermal drug sensitivity tests can detect the presence of following type of hypersensitivity:
A. Type I (anaphylactic)
B. Type II (cytolytic)
C. Type III (retarded)
D. All of the above
4.15 An addicting drug which produces little or no physical
dependence is:
A. Diazepam
B. Phenobarbitone
C. Amphetamine
D. Methadone
4.16 The essential feature in drug addiction is:
A. Physical dependence
B. Psychological dependence
C. Both physical and psychological dependence
D. Psychiatric abnormality
4.17 Adaptive neurophysiological changes produced by repeated administration of a drug, which result in the appearance of characteristic withdrawal syndrome on discontinuation of the drug is called:
A. Drug addiction
B. Drug abuse
C. Psychological dependence
D. Physical dependence
4.18 Which of the following constitutes ‘drug abuse’:
A. Physician prescribed use of penicillin G for the cure of viral fever
B. Self administration of aspirin to relieve headache
C. Repeated self administration of morphine to derive euphoria
D. All of the above
4.19 ‘Addiction’ and ‘habituation’:
A. Are fundamentally different phenomena
B. Are produced by different set of drugs/substances
C. Differ from one another by the presence or absence of physical dependence
D. Differ from each other in the degree of attendant psychological dependence
4.20 Adverse consequences may follow sudden discontinuation of the following drug after chronic intake:
A. Cocaine
B. Cannabis
C. Clonidine
D. All of the above
4.21 The most vulnerable period of pregnancy for the causation of foetal malformations due to drugs is:
A. 18-55 days of gestation
B. 56-84 days of gestation
C. Second trimester
D. 36 weeks onwards
4.22 The following is a proven human teratogen:
A. Chloroquine
B. Warfarin sodium
C. Dicyclomine
D. Methyldopa
4.23 Select the drug which has been found to be a strong human teratogen:
A. Isoniazid
B. Isotretinoin
C. Hydralazine
D. Propylthiouracil
4.1 A 4.2 C 4.3 A 4.4 B 4.5 C 4.6 C 4.7 B 4.8 A 4.9 B 4.10 B 4.10 A 4.11 C 4.12 C 4.12 C 4.13 C 4.13 C 4.14 C 4.14 A 4.15 A 4.15 C 4.16 B 4.17 B 4.17 D 4.18 D 4.18 C 4.19 D 4.20 C 4.21 C 4.21 A 4.22 A 4.22 B 4.23 B