A. Histamine
B. 5-Hydroxy tryptamine
C. Dopamine
D. Noradrenaline
11.2 The following action of 5 Hydroxy tryptamine is mediated by the 5-HT3 receptor:
A. Vasoconstriction
B. Bradycardia
C. EDRF release
D. Platelet aggregation
11.3 The typical response to intravenous injection of 5-HT in an anaesthetised animal is:
A. Rise in BP
B. Fall in BP
C. Rise followed by brief fall in BP
D. Transient fall, followed by brief rise, followed by prolonged fall in BP
11.4 The following 5-HT receptor is not a G protein coupled receptor:
A. 5-HT1
B. 5-HT2
C. 5-HT3
D. 5-HT4
11.5 Tachyphylaxis to many actions on repeated injection is a feature of the following autacoid:
A. Histamine
B. 5-Hydroxytryptamine
C. Bradykinin
D. Prostaglandin E2
11.6 The following is a selective 5-HT1D receptor agonist:
A. Buspirone
B. Ondansetron
C. Sumatriptan
D. α-methyl 5-HT
11.7 Actions of 5-HT2 receptor activation are primarily mediated by:
A. Increased membrane permeability to Na+ ions
B. Increased formation of cAMP
C. Activation of guanylyl cyclase
D. Generation of inositol trisphosphate and diacyl glycerols
11.8 The following serotonergic receptor functions primarily as an autoreceptor on neurones:
A. 5-HT1A
B. 5-HT2A
C. 5-HT3
D. 5-HT4
11.9 The smooth muscle stimulating action of 5-HT is most marked in the:
A. Bronchi
B. Intestines
C. Ureter
D. Biliary tract
11.10 5-HT appears to play a role in the following except:
A. Regulation of normal BP
B. Regulation of intestinal peristalsis
C. Haemostasis
D. Causation of migraine
11.11 The most important receptor involved in cytotoxic drug induced vomiting is:
A. Histamine H1 receptor
B. Serotonin 5-HT3 receptor
C. Dopamine D2 receptor
D. Opioid μ receptor
11.12 The following is a selective 5-HT4 agonist:
A. Buspirone
B. Sumatriptan
C. Cisapride
D. Clozapine
11.13 Methysergide has lost popularity as a prophylactic drug for migraine because of its:
A. Poor efficacy
B. Potential to cause visceral fibrosis
C. Oxytocic action
D. Potential to aggravate ischaemic heart disease
11.14 Blockade of both dopamine D2 and serotonin 5-HT2A/2C receptors is a distinctive feature of:
A. Pimozide
B. Haloperidol
C. Ketanserin
D. Clozapine
11.15 Dihydroergotamine (DHE) differs from ergotamine in the following respect:
A. It is a more potent oxytocic
B. It has antiemetic property
C. It has high oral bioavailability
D. It is a more potent α adrenergic blocker and less potent vasoconstrictor
11.16 Choose the ergot alkaloid that is well absorbed orally, has weak vascular but prominent uterine stimulant action:
A. Ergometrine
B. Ergotamine
C. Dihydroergotamine
D. Dihydroergotoxine
11.17 Select the ergot compound which is primarily used for dementia:
A. Bromocriptine
B. Ergotamine
C. Codergocrine
D. Methysergide
11.18 The ‘amine’ ergot alkaloid differs from ‘amino acid’ ergot alkaloid in that it has:
A. High oral bioavailability
B. Better CNS penetrability
C. Weaker oxytocic action
D. Strong anti-5-HT action
11.19 Select the correct statement in relation to drug therapy of migraine:
A. Simple analgesics like paracetamol are ineffective in migraine
B. Ergot alkaloids are used for prophylaxis as well as treatment of migraine attacks
C. Use of ergot alkaloids is restricted to severe or resistant cases
D. Ergot alkaloids should be given till 24 hours after an attack has subsided
11.20 The nonsteroidal anti inflammatory drugs are more effective in migraine:
A. Without aura
B. With aura
C. Than ergotamine
D. When combined with propranolol
11.21 Ergotamine relieves migraine by:
A. Blocking vascular α adrenergic receptors
B. Blocking vascular 5-HT2 receptors
C. Dilating cranial arterio-venous shunt channels
D. Constricting cranial vessels and reducing perivascular neurogenic inflammation
11.22 The most important risk in the use of sumatriptan for treatment of migraine is:
A. Precipitation of seizures
B. Precipitation of psychosis
C. Development of hypertension
D. Coronary vasospasm
11.23 Choose the correct statement about sumatriptan:
A. It activates serotonergic neurones in raphe nuclei
B. It tends to suppress both pain and vomiting in migraine
C. It does not carry risk of precipitating coronary vasospasm
D. It is combined with ergotamine for treatment of severe migraine
11.24 Which of the following drugs is most commonly used for prophylaxis of migraine:
A. Ergotamine
B. Propranolol
C. Methysergide
D. Sumatriptan
11.25 Select the β blocker which does not afford prophylaxis in migraine:
A. Propranolol
B. Timolol
C. Atenolol
D. Pindolol
11.26 Prophylactic therapy of migraine:
A. Is recommended in all cases
B. Benefits upto 70% patients of moderate to severe migraine
C. Needs to be continued lifelong without interruption
D. Reduces the severity but increases the frequency of migraine attacks
11 .1 A 11.2 B 11.3 D 11.4 C 11.5 B 11.6 C 11.7 D 11.8 A 11.9 B 11.10 A 11.11 B 11.12 C 11.13 B 11.14 D 11.15 D 11.16 A 11.17 C 11.18 A 11.19 C 11.20 A 11.21 D 11.22 D 11.23 B 11.24 B 11.25 D 11.26 B