MCQs-Drugs Acting on Central Nervous System part 9 I Pharmacology KD Tripathi mcqs part 33

 33.1 Strychnine produces convulsions by:

A. Stimulating NMDA receptors

B. Facilitating the excitatory transmitter glutamate

C. Blocking the inhibitory transmitter GABA

D. Blocking the inhibitory transmitter glycine

33.2 The following drug has been used to stimulate respiratory

and vasomotor centres as an expedient measure,

because it has the least propensity to induce

convulsions:

A. Pentylenetetrazole

B. Doxapram

C. Bicuculline

D. Amphetamine

33.3 The drug of choice for hyperkinetic children is:

A. Methylphenidate

B. Nikethamide

C. Caffeine

D. Clonazepam 

33.4 The neurotransmitter system in the brain most

affected in Alzheimer’s disease is:

A. Glutaminergic

B. Gabaergic

C. Dopaminergic

D. Cholinergic

33.5 Hepatotoxicity has markedly restricted use of the

following cerebroselective anticholinesterase in

Alzheimer's disease:

A. Rivastigmine

B. Tacrine

C. Galantamine

D. Donepezil 

33.6 The following is true of rivastigmine except:

A. It is a relatively selective inhibitor of G1 isoform of acetylcholinesterase

B. It has been found to retard disease progression in Alzheimer's disease

C. It affords measurable improvement in Alzheimer's disease symptom score

D. It enhances cerebral cholinergic transmission with only mild peripheral effect

33.7 Indications of piracetam include the following except:

A. Apnoea in preterm infant

B. Learning defects in children

C. Confusional states in the elderly

D. Memory impairment following electroconvulsive

therapy 

33.8 The following drug claimed to have a therapeutic

effect in senile dementia has α adrenergic blocking

activity:

A. Piracetam

B. Pyritinol

C. Codergocrine

D. Methylphenidate 

33.9 Select the drug that improves some symptoms in

Alzheimer’s dementia by increasing brain acetylcholine

levels:

A. Pemoline

B. Donepezil

C. Nicergoline

D. Piribedil 

33.10 Select the correct statement abut donepezil:

A. It is a topical carbonic anhydrase inhibitor used in glaucoma

B. It is a catechol-'O'-methyl transferase

inhibitor used as adjuvant in parkinson's

disease

C. It is a cerebroselective anticholinesterase

that affords symptomatic improvement in

Alzheimer's disease

D. It is a synthetic cannabinoid with antiemetic property

33.11 Pyritinol (pyrithioxine) is used as:

A. Analeptic drug

B. Cognition enhancing drug

C. Antiepileptic drug

D. Antidepressant drug

33.12 Extract of the following plant has platelet activating

factor (PAF) antagonistic activity and is claimed to

benefit cognitive disorders due to cerebral ischaemia:

A. Ginkgo biloba

B. Claviceps purpurea

C. Amanita muscaria

D. Artemisia annua

Ans:

33.1D 33.2 B 33.3 A 33.4D 33.5 B 33.6 B 33.7 A 33.8 C 33.9 B 33.10 C 33.11 B 33.12 A