MCQs-Drugs Acting on Kidney part 2 I Pharmacology KD Tripathi mcqs part 40

 40.1 Which of the following peptides is a selective vasopressin V2 receptor agonist:

A. Arginine vasopressin

B. Desmopressin

C. Lypessin

D. Terlipressin

40.2 The primary mechanism by which antidiuretic hormone

reduces urine volume is:

A. Decrease in glomerular filtration rate

B. Decreased renal blood flow

C. Decreased water permeability of descending limb of loop of Henle

D. Increased water permeability of collecting duct cells

40.3 The vasopressin action(s) mediated by V2 receptors include(s):

A. Increased water permeability of collecting duct cells

B. Increased urea permeability of collecting duct cells

C. Vasoconstriction

D. Both 'A' and 'B'

40.4 Desmopressin is preferred over arginine vasopressin

in the treatment of diabetes insipidus for the following

reasons except:

A. It is a more potent antidiuretic

B. It is a selective vasopressin V1 receptor agonist

C. It has little vasoconstrictor activity

D. It is longer acting

40.5 Select the action of vasopressin exerted through the

V1 subtype receptors:

A. Release of coagulation factor VIII and von

Willebrands factor from vascular endothelium

B. Increased peristalsis of gut

C. Dilatation of blood vessels

D. Increased water permeability of renal collecting ducts

40.6 The following tissue is most sensitive to vasopressin:

A. Renal collecting ducts

B. Intestinal smooth muscle

C. Vascular smooth muscle

D. Uterus

40.7 Desmopressin reduces urine volume in:

A. Neurogenic diabetes insipidus

B. Nephrogenic diabetes insipidus

C. Both neurogenic as well as nephrogenic diabetes insipidus

D. Normal individuals but not in diabetes insipidus

 

40.8 Choose the correct statement(s) about terlipressin:

A. It is a prodrug

B. It is used to control bleeding from esophageal varices

C. It is preferred for controlling bleeding in von Willebrand's disease

D. Both 'A' and 'B' are correct

40.9 The following is true of desmopressin except:

A. It is nonselective V1 and V2 receptor agonist

B. It is more potent and longer acting than arginine vasopressin (AVP)

C. It is preferred over AVP for treatment of  diabetes insipidus

D. It can be administered orally

40.10 Indications of desmopressin include the following except:

A. Neurogenic diabetes insipidus

B. Nephrogenic diabetes insipidus

C. Bedwetting in children

D. Bleeding due to haemophilia

40.11 Arginine vasopressin is preferred over desmopressin in the following condition:

A. Diabetes insipidus

B. Bedwetting in children

C. Bleeding esophageal varices

D. Bleeding in haemophilia

40.12 The following drug reduces urine volume in both

pituitary origin as well as renal diabetes insipidus and

is orally active:

A. Vasopressin

B. Hydrochlorothiazide

C. Chlorpropamide

D. Carbamazepine

Ans: 40.1 B 40.2 D 40.3D 40.4 B 40.5 B 40.6 A  40.7 A 40.8D 40.9 A 40.10 B 40.11 C 40.12 B