MCQs-Antimicrobial Drugst Part 5 I Pharmacology KD Tripathi mcqs part 51

 

51.1 Aminoglycoside antibiotics have the following property common to all members:

A. They are primarily active against aerobic gram negative bacilli

B. They are more active in acidic medium

C. They readily enter cells and are distributed in total body water

D. They are nearly completely metabolized in liver

51.2 Which aminoglycoside antibiotic causes more hearing

loss than vestibular disturbance as toxic effect:

A. Streptomycin

B. Gentamicin

C. Kanamycin

D. Sisomicin

51.3 Select the class of antibiotics which act by interfering

with bacterial protein synthesis, but are bactericidal:

A. Tetracyclines

B. Aminoglycosides

C. Macrolides

D. Lincosamides

51.4 The antibacterial action of aminoglycoside antibiotics is characterized by:

A. Concentration dependent rate of bacterial cell killing

B. Concentration dependent prolonged postantibiotic effect

C. More pronounced bactericidal effect in anaerobic medium

D. Both 'A' and 'B' are correct

51.5 The following antibiotic(s) exert(s) a long postantibiotic effect:

A. Fluoroquinolones

B. β-lactams

C. Aminoglycosides

D. All of the above

51.6 Aminoglycoside antibiotics exert the following action(s) on sensitive bacteria:

A. Induce synthesis of defective proteins

B. Make bacterial cell membrane more leaky

C.  Augment their own carrier mediated entry into the bacteria

D. All of the above

51.7 Bactericidal action of aminoglycoside antibiotics is due to:

A. Inhibition of bacterial protein synthesis

B. Alteration of bacterial cell membrane permeability

C. Damage to bacterial cell wall

D. Inhibition of bacterial oxidative metabolism

51.8 Cross resistance among different members of the

following class of antimicrobials is absent / incomplete

or unidirectional:

A. Aminoglycosides

B. Macrolides

C. Tetracyclines

D. Both ‘B’ and ‘C’ are correct

51.9 The most important mechanism of bacterial resistance to an aminoglycoside antibiotic is:

A. Plasmid mediated acquisition of aminoglycoside conjugating enzyme

B. Mutational acquisition of aminoglycoside hydrolysing enzyme

C. Mutation reducing affinity of ribosomal protein for the antibiotic

D. Mutational loss of porin channels

 

51.10 Streptomycin sulfate is not absorbed orally because it is:

A. Degraded by gastrointestinal enzymes

B. Destroyed by gastric acid

C. Highly ionized at a wide range of pH values

D. Insoluble in water

51.11 The following is true for gentamicin:

A. It is more active in acidic medium

B. It has a wide margin of safety

C. It is excreted unchanged, mainly by glomerular filtration

D. It primarily inhibits gram positive bacteria

51.12 A 60-year-old patient with creatinine clearance 50

ml/min has to be treated with gentamicin.

His daily dose of gentamicin should be reduced to

the following percentage of the usual adult dose:

A. 70%

B. 50%

C. 40%

D. 30%

51.13 Gentamicin differs from streptomycin in that:

A. It is less nephrotoxic

B. It is used for pseudomonas infections

C. It is not effective in tuberculosis

D. Both ‘B’ and ‘C’ are correct

51.14 Select the antibiotic which is equally effective

whether injected 8 hourly or 24 hourly, provided the

total daily dose remains the same:

A. Gentamicin

B. Sod. penicillin G

C. Cefazolin

D. Vancomycin

51.15 The aminoglycoside antibiotic which is distinguished

by its resistance to bacterial aminoglycoside

inactivating enzymes is:

A. Kanamycin

B. Sisomicin

C. Amikacin

D. Tobramycin

51.16 Concurrent use of an aminoglycoside antibiotic

should be avoided with the following antibiotic:

A. Ampicillin

B. Vancomycin

C. Ciprofloxacin

D. Rifampin

51.17 Oral neomycin is beneficial in hepatic coma because:

A. In hepatic failure patients it is absorbed from the intestines

B. It decreases ammonia production by gut bacteria

C. It reacts chemically with ammonia in the gut to prevent its diffusion into blood

D. It induces ammonia detoxifying enzymes in the liver

51.18 Neomycin is widely used as a topical antibiotic because:

A. It is active against a wide range of bacteria causing superfecial infections

B. It rarely causes contact sensitization

C. It is poorly absorbed from the topical sites of application

D. All of the above are correct

51.19 Prolonged oral therapy with the following antibiotic

can damage intestinal villi resulting in steatorrhoea

and loose motions:

A. Ampicillin

B. Tetracycline

C. Neomycin

D. Nystatin

Ans:

51.1 A 51.2 C 51.3 B 51.4D 51.5D 51.6D 51.7 B 51.8 A 51.9 A 51.10 C 51.11 C 51.12 B 51.13D 51.14 A 51.15 C 51.16 B 51.17 B 51.18D 51.19 C