7.1 Initial bradycardia caused by intramuscular injection of atropine is believed to be caused by:
A. Stimulation of medullary vagal centre
B. Stimulation of vagal ganglia
C. Blockade of M2 receptors on SA nodal cells
D. Blockade of muscarinic autoreceptors on vagal nerve endings
7.2 Atropine does not exert relaxant/antispasmodic effect on the following muscle:
A. Intestinal
B. Ureteric
C. Bronchial
D. Laryngeal
7.3 Atropine produces the following actions except:
A. Tachycardia
B. Mydriasis
C. Dryness of mouth
D. Urinary incontinence
7.4 The organ most sensitive to actions of atropine is:
A. Gastric glands
B. Salivary glands
C. Urinary bladder muscle
D. Heart
7.5 Hyoscine differs from atropine in that it:
A. Exerts depressant effects on the CNS at relatively low doses
B. Exerts more potent effects on the heart than on the eye
C. Is longer acting
D. Has weaker antimotion sickness activity
7.6 The quarternary analogues of belladonna alkaloids are preferred over the natural alkaloids for antisecretory/ antispasmodic indications because:
A. They have additional nicotinic receptor blocking activity
B. They are incompletely absorbed after oral administration
C. They are devoid of CNS and ocular effects
D. Dose to dose they are more potent than atropine
7.7 Inhaled ipratropium bromide has the following advantages except:
A. It does not alter respiratory secretions
B. It does not depress airway mucociliary clearance
C. It has faster onset of bronchodilator action than inhaled salbutamol
D. It only rarely produces systemic side effects
7.8 Which of the following anticholinergic drugs is primarily
used in preanaesthetic medication and during surgery:
A. Glycopyrrolate
B. Pipenzolate methyl bromide
C. Isopropamide
D. Dicyclomine
7.9 Children are more susceptible than adults to the following action of atropine:
A. Tachycardia producing
B. Cycloplegic
C. Gastric antisecretory
D. Central excitant and hyperthermic
7.10 Glycopyrrolate is the preferred antimuscarinic drug for use before and during surgery because:
A. It is potent and fast acting
B. It has no central action
C. It has antisecretory and vagolytic actions
D. All of the above
7.11 Choose the relatively vasicoselective anticholinergic
drug used for urinary frequency and urge incontinence due to detrusor instability:
A. Pirenzepine
B. Oxybutynin
C. Oxyphenonium
D. Glycopyrolate
7.12 Which of the following mydriatics has the fastest and
briefest action:
A. Atropine
B. Homatropine
C. Tropicamide
D. Cyclopentolate
7.13 The following mydriatic does not produce cycloplegia:
A. Phenylephrine
B. Tropicamide
C. Cyclopentolate
D. Homatropine
7.14 The most suitable mydriatic for a patient of corneal ulcer is:
A. Atropine sulfate
B. Homatropine
C. Cyclopentolate
D. Tropicamide
7.15 The mydriatic incapable of producing cycloplegia sufficient for refraction testing in children is:
A. Atropine
B. Hyoscine
C. Homatropine
D. Cyclopentolate
7.16 Choose the correct statement about drotaverine:
A. It is a smooth muscle antispasmodic acting by non-anticholinergic mechanisms
B. It is a papaverine congener used in peripheral vascular diseases
C. It is a synthetic atropine substitute used to control diarrhoea
D. It is a M1/M3 selective antagonist used for spastic constipation
7.17 The most effective antidote for belladonna poisoning is:
A. Neostigmine
B. Physostigmine
C. Pilocarpine
D. Methacholine
7.18 Atropine is contraindicated in:
A. Pulmonary embolism
B. Digitalis toxicity
C. Iridocyclitis
D. Raised intraocular tension
7.19 Choose the correct statement about nicotine:
A. It selectively stimulates parasympathetic ganglia
B. It has no clinical application
C. It is used as an aid during smoking cessation
D. It is used in Alzheimer's disease
7.20 Ganglion blocking drugs are no longer used in therapeutics because:
A. They have few and weak pharmacological actions
B. They produce many side effects
C. They are inactive by oral route
D. They have short duration of action
7.1 D 7.2 D 7.3 D 7.4 B 7.5 A 7.6 C 7.7 C 7.8 A 7.9 D 7.10 D 7.11 B 7.12 C 7.13 A 7.14 A 7.15 C 7.16 A 7.17 B 7.18 D 7.19 C 7.20 B