9.1 Adrenergic neurone blocking drugs:
A. Block the action of adrenaline on neuronal α2 adrenoceptors
B. Block both α and β adrenoceptor mediated effects of injected adrenaline
C. Do not block any effect of injected adrenaline
D. Do not block the effects of sympathetic nerve stimulation
9.2 The nonselective α adrenergic blockers produce the following actions except:
A. Postural hypotension
B. Bradycardia
C. Miosis
D. Inhibition of ejaculation
9.3 The drug which produces vasoconstriction despite being an α adrenergic blocker is:
A. Phenoxybenzamine
B. Ergotamine
C. Dihydroergotoxine
D. Tolazoline
9.4 The bladder trigone and prostatic muscles are relaxed by:
A. Adrenergic α1 agonists
B. Adrenergic α1 antagonists
C. Adrenergic α2 agonists
D. Adrenergic α2 antagonists
9.5 The primary reason for preferring phentolamine as the α adrenergic blocker for performing diagnostic test for pheochromocytoma is:
A. It produces rapid and short lasting α-adrenergic blockade
B. It equally blocks α1 and α2 adrenoceptors
C. It is the most potent α blocker
D. It has no additional β adrenergic blocking property
9.6 Prazosin is an effective anti hypertensive while nonselective α adrenergic blockers are not because:
A. It is the only orally active α blocker
B. It improves plasma lipid profile
C. It does not concurrently enhance noradrenaline release
D. It improves urine flow in males with prostatic hypertrophy
9.7 Phentolamine test is considered positive for pheochromocytoma if there is a:
A. Rise in BP by more than 35 mm Hg systolic and 25 mm Hg diastolic
B. Rise in systolic but fall in diastolic BP
C. Fall in both systolic and diastolic BP by less than 20 mm Hg
D. Fall in BP by more than 35 mm Hg systolic and more than 25 mm Hg diastolic
9.8 Select the drug which affords faster and greater symptomatic relief in benign hypertrophy of prostate:
A. Terazosin
B. Desmopressin
C. Finasteride
D. Sildenafil
9.9 Select the drug which can improve urinary flow rate in benign prostatic hypertrophy without affecting prostate size:
A. Amphetamine
B. Prazosin
C. Finasteride
D. Goserelin
9.10 Which of the following is a selective α1A receptor blocker that affords symptomatic relief in benign prostatic hypertrophy without producing significant fall in blood
pressure:
A. Terazosin
B. Doxazosin
C. Trimazosin
D. Tamsulosin
9.11 Sildenafil is contraindicated in patients taking the following class of drugs:
A. α-adrenergic blockers
B. β-adrenergic blockers
C. Organic nitrates
D. Angiotensin converting enzyme inhibitors
9.12 What is true of sildenafil:
A. It enhances sexual enjoyment in normal men
B. It delays ejaculation
C. It improves penile tumescence in men with erectile dysfunction
D. It blocks cavernosal α2 adrenoceptors
9.13 Select the drug which is administered orally for erectile
dysfunction in men:
A. Yohimbine
B. Papaverine
C. Alprostadil
D. Sildenafil
9.14 The β adrenergic blocker having β1 selectivity, intrinsic sympathomimetic activity and membrane stabilizing
property is:
A. Carvedilol
B. Atenolol
C. Acebutolol
D. Metoprolol
9.15 All of the following contribute to the antihypertensive action of propranolol except:
A. Direct vasodilatation
B. Decreased renin release from kidney
C. Adaptation of blood vessels to reduced cardiac output
D. Less noradrenaline release from sympathetic nerve endings
9.16 The effect of propranolol on heart rate is least marked under the following condition:
A. Physical exercise
B. Rest
C. Anxiety
D. Sick sinus syndrome
9.17 Propranolol can be used to allay anxiety associated with:
A. Chronic neurotic disorder
B. Schizophrenia
C. Short-term stressful situations
D. Endogenous depression
9.18 Propranolol does not block the following action of adrenaline:
A. Bronchodilatation
B. Lipolysis
C. Muscle tremor
D. Mydriasis
9.19 Which of the following drugs attenuates the antihypertensive action of β-blockers:
A. Cimetidine
B. Indomethacin
C. Chlorpromazine
D. Imipramine
9.20 Select the drug which can impair carbohydrate tolerance
in prediabetics but prolongs insulin hypoglycaemia:
A. Salbutamol
B. Propranolol
C. Prazosin
D. Nifedipine
9.21 The following disease is worsened by propranolol:
A. Glaucoma
B. Raynaud’s disease
C. Benign prostatic hypertrophy
D. Parkinsonism
9.22 β-adrenergic blockers are indicated in the following
conditions except:
A. Hypertrophic cardiomyopathy
B. Congestive heart failure
C. Vasospastic angina pectoris
D. Dissecting aortic aneurysm
9.23 Select the ultrashort acting cardioselective β adrenergic blocker:
A. Bisoprolol
B. Timolol
C. Sotalol
D. Esmolol
9.24 Esmolol has the following features except:
A. Rapidly developing, shortlasting β adrenergic blockade
B. Cardioselectivity of action
C. Intrinsic sympathomimetic activity
D. Suitability for intraoperative use
9.25 In a patient of hypertension, the dose of propranolol that normalized blood pressure, reduced resting heart
rate to 50/min. Which of the following β blockers will be most suitable for him as an alternative so that heart rate is not markedly reduced:
A. Pindolol
B. Celiprolol
C. Bisoprolol
D. Atenolol
9.26 In patients of congestive heart failure, β-adrenergic blockers:
A. Are absolutely contraindicated
B. Can prolong survival
C. Can improve haemodynamics after compensation has been restored
D. Both B and C are correct
9.27 The basis for use of β-adrenergic blockers in congestive heart failure (CHF) is:
A. They exert positive inotropic effect in CHF
B. They counteract deleterious effect of sympathetic overactivity on the myocardium
C. They exert antiischaemic effect on the heart
D. They prevent cardiac arrhythmias
9.28 Adrenergic β1 selective blocker offer the following advantages except:
A. Lower propensity to cause bronchospasm
B. Less prone to produce cold hands and feet as side effect
C. Withdrawal is less likely to exacerbate angina pectoris
D. Less liable to impair exercise capacity
9.29 The following is not a feature of cardioselective beta blockers, when compared to propranolol:
A. They are ineffective in suppressing muscle tremor
B. They are safer in diabetics
C. They are less likely to cause bradycardia
D. They are less likely to worsen Raynaud’s disease
9.30 Select the β adrenergic blocker that is primarily eliminated unchanged by renal excretion:
A. Propranolol
B. Metoprolol
C. Esmolol
D. Atenolol
9.31 In a patient of myocardial infarction, β adrenergic blockers are used with the following aim/aims:
A. To reduce the incidence of reinfarction
B. To prevent cardiac arrhythmias
C. To limit size of the infarct
D. All of the above
9.32 Select the β-adrenergic blocker that has additional α1 blocking, vasodilator and antioxidant properties:
A. Carvedilol
B. Celiprolol
C. Acebutolol
D. Metoprolol
9.33 In hyperthyroidism, β adrenergic blockers are used:
A. To induce euthyroid state
B. As definitive therapy
C. For rapid control of certain symptoms while
awaiting response to carbimazole
D. To reduce basal metabolic rate
9.34 Select the drug that suppresses essential tremor, but not parkinsonian tremor:
A. Procyclidine
B. Propranolol
C. Promethazine
D. Prochlorperazine
9.35 Labetalol has:
A. More potent β adrenergic blocking than α blocking activity
B. More potent α adrenergic blocking than β blocking activity
C. Equal α and β adrenergic blocking activity
D. β1 agonistic activity in addition to α and β adrenergic blockade
9.36 Labetalol differs from propranolol in that:
A. It has additional α1 blocking property
B. It is a selective β1 blocker
C. It does not undergo first pass metabolism
D. All of the above
9.1 C 9.2 B 9.3 B 9.4 B 9.5 A 9.6 C 9.7 D 9.8 A 9.9 B 9.10 D 9.11 C 9.12 C 9.13 D 9.14 C 9.15 A 9.16 B 9.17 C 9.18 D 9.19 B 9.20 B 9.21 B 9.22 C 9.23 D 9.24 C 9.25 A 9.26 D 9.27 B 9.28 C 9.29 C 9.30 D 9.31 D 9.32 A 9.33 C 9.34 B 9.35 A 9.36 A