>>>Part 3
45.1 The most dependable emetic used to expel ingested poisons is:
A. Intramuscular emetine
B. Oral syrup ipecacuanha
C. Intramuscular apomorphine
D. Oral bromocriptine
45.2 In a conscious patient of poisoning, use of an emetic
is permissible in case the ingested poison is:
A. Ferrous sulfate
B. Sodium hydroxide
C. Kerosine
D. Morphine
45.3 The most effective antimotion sickness drug suitable for short brisk journies is:
A. Promethazine theoclate
B. Cinnarizine
C. Prochlorperazine
D. Hyoscine
45.4 In case of hill journey, antimotion sickness drugs are best administered at:
A. Twelve hours before commencing journey
B. One hour before commencing journey
C. Immediately after commencing journey
D. At the first feeling of motion sickness
45.5 Chlorpromazine and its congeners suppress vomiting
of following etiologies except:
A. Motion sickness
B. Radiation sickness
C. Postanaesthetic
D. Uremic
45.6 Choose the phenothiazine compound which has selective
labyrinthine suppressant action, is used for
vomiting and vertigo, but not in schizophrenia:
A. Triflupromazine
B. Prochlorperazine
C. Trifluoperazine
D. Thioridazine
45.7 Metoclopramide has the following actions except:
A. Increases lower esophageal sphincter tone
B. Increases tone of pyloric sphincter
C. Increases gastric peristalsis
D. Increases intestinal peristalsis
45.8 Metoclopramide blocks apomorphine induced vomiting,
produces muscle dystonias and increases prolactin
release indicates that it has:
A. Anticholinergic action
B. Antihistaminic action
C. Anti 5-HT3 action
D. Antidopaminergic action
45.9 Activation of the following type of receptors present
on myenteric neurones by metoclopramide is primarily
responsible for enhanced acetylcholine release
improving gastric motility:
A. Muscarinic M1
B. Serotonergic 5-HT3
C. Serotonergic 5-HT4
D. Dopaminergic D2
45.10 Select the prokinetic-antiemetic drug which at relatively
higher doses blocks both dopamine D2 as well
as 5-HT3 receptors and enhances acetylcholine
release from myenteric neurones:
A. Cisapride
B. Prochlorperazine
C. Metoclopramide
D. Domperidone
45.11 Which prokinetic drug(s) produce(s) extrapyramidal side effects:
A. Metoclopramide
B. Cisapride
C. Domperidone
D. All of the above
45.12 The progastrokinetic action of the following drug(s) is attenuated by atropine:
A. Domperidone
B. Metoclopramide
C. Cisapride
D. Both ‘B’ and ‘C’
45.13 A patient returning from dinner party meets with road
accident and has to be urgently operated upon under
general anaesthesia. Which drug can be injected
intramuscularly to hasten his gastric emptying:
A. Methylpolysiloxane
B. Promethazine
C. Metoclopramide
D. Apomorphine
45.14 Select the correct statement regarding the antiemetic
efficacy of the three prokinetic drugs metoclopramide,
domperidone and cisapride:
A. Cisapride is the most effective
B. Metoclopramide is the most effective
C. Domperidone is the most effective
D. All three are equally efficacious
45.15 Which antiemetic selectively blocks levodopa induced
vomiting without blocking its antiparkinsonian action:
A. Metoclopramide
B. Cisapride
C. Domperidone
D. Ondansetron
45.16 The following prokinetic drug has been implicated in
causing serious ventricular arrhythmias, particularly
in patients concurrently receiving erythromycin or
ketoconazole:
A. Domperidone
B. Cisapride
C. Mosapride
D. Metoclopramide
45.17 Indicate the drug which does not improve lower
esophageal sphincter tone or prevent gastroesophageal
reflux, but is used as first line treatment of
gastroesophageal reflux disease:
A. Sodium alginate + aluminium hydroxide gel
B. Omeprazole
C. Mosapride
D. Famotidine
45.18 Select the drug(s) which afford(s) relief in gastroesophageal
reflux by increasing lower esophageal
sphincter tone and promoting gastric emptying, but
without affecting acidity of gastric contents:
A. Sodium alginate
B. Metoclopramide
C. Cisapride
D. Both ‘B’ and ‘C’
45.19 The fastest symptomatic relief as well as highest
healing rates in reflux esophagitis are obtained with:
A. Prokinetic drugs
B. H2 receptor blockers
C. Proton pump inhibitors
D. Sodium alginate
45.20 Prokinetic drugs serve the following purpose(s) in
gastroesophageal reflux disease:
A. Reduce reflux of gastric contents into esophagus
B. Promote healing of esophagitis
C. Reduce acidity of gastric contents
D. Both ‘A’ and ‘B’ are correct
45.21 Cisapride enhances gastrointestinal motility by:
A. Activating serotonin 5-HT4 receptor
B. Activating muscarinic M3 receptor
C. Blocking dopamine D2 receptor
D. All of the above
45.22 The most effective antiemetic for controlling cisplatin
induced vomiting is:
A. Prochlorperazine
B. Ondansetron
C. Metoclopramide
D. Promethazine
45.23 Select the antiemetic that prevents activation of
emetogenic afferents in the gut and their central relay
in chemoreceptor trigger zone/nucleus tractus
solitarious, but has no effect on gastric motility:
A. Ondansetron
B. Domperidone
C. Metoclopramide
D. Cisapride
45.24 Granisetron is a:
A. Second generation antihistaminic
B. Drug for peptic ulcer
C. Antiemetic for cancer chemotherapy
D. New antiarrhythmic drug
45.25 Ondansetron is effective in the following type(s) of vomiting:
A. Cisplatin induced
B. Radiotherapy induced
C. Postoperative
D. All of the above
45.26 Ondansetron blocks emetogenic impulses at the following site(s):
A. Vagal afferents in intestines
B. Nucleus tractus solitarius
C. Chemoreceptor trigger zone
D. All of the above
45.27 Choose the correct statement about ondansetron:
A. It is a dopamine D2 receptor antagonist
B. It suppresses postoperative nausea and vomiting
C. It is the most effective antiemetic for motion sickness
D. It is not effective by oral route
45.28 Cancer chemotherapy induced vomiting that is not
controlled by metoclopramide alone can be suppressed
by combining it with:
A. Amphetamine
B. Dexamethasone
C. Hyoscine
D. Cyclizine
45.29 Prolonged treatment with the following drug can
promote dissolution of gallstones if the gall bladder is functional:
A. Ursodeoxycholic acid
B. Sodium taurocholate
C. Sodium glycocholate
D. Cholecystokinin
Ans:
45.1 C 45.2 A 45.3D 45.4 B 45.5 A 45.6 B 45.7 B 45.8D 45.9 C 45.10 C 45.11 A 45.12D 45.13 C 45.14 B 45.15 C 45.16 B 45.17 B 45.18D 45.19 C 45.20 A 45.21 A 45.22 B 45.23 A 45.24 C 45.25D 45.26D 45.27 B 45.28 B 45.29 A
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