MCQs-Antimicrobial Drugst Part 8 I Pharmacology KD Tripathi mcqs part 54

 

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54.1 The most important dose dependent toxicity of dapsone is:

A. Methemoglobinemia

B. Haemolysis

C. Hepatitis

D. Dermatitis

54.2 The following is true of clofazimine except:

A. It is cidal to Mycobacterium leprae

B. It has additional antiinflammatory property

C. It has a very long elimination half life

D. It discolours skin and sweat

54.3 Which fluoroquinolone is highly active against

Mycobact. leprae and is being used in alternative

multidrug therapy regimens:

A. Norfloxacin

B. Ofloxacin

C. Ciprofloxacin

D. Lomefloxacin

54.4 The tetracycline with highest antileprotic activity is:

A. Minocycline

B. Doxycycline

C. Demeclocycline

D. Oxytetracycline

54.5 Select the macrolide antibiotic having clinically useful

antileprotic activity:

A. Azithromycin

B. Clarithromycin

C. Erythromycin

D. Roxithromycin

54.6 Multidrug therapy with dapsone + rifampin ± clofazimine

is the treatment of choice for:

A. Multibacillary leprosy

B. Paucibacillary leprosy

C. Dapsone resistant leprosy

D. All forms of leprosy

54.7 Currently, monotherapy of leprosy with dapsone is

recommended for:

A. Paucibacillary leprosy only

B. Multibacillary leprosy only

C. Both paucibacillary and multibacillary leprosy

D. Neither paucibacillary nor multibacillary leprosy

54.8 The multidrug therapy of leprosy is superior to monotherapy on the following account(s):

A. It prevents emergence of dapsone resistance

B. It is effective in cases with primary dapsone resistance

C. It shortens the total duration of drug therapy and improves compliance

D. All of the above

54.9 If a multibacillary leprosy patient treated with standard

fixed duration multidrug therapy relapses, he should

be treated with:

A. The same rifampin + dapsone + clofazimine regimen

B. Clofazimine + ofloxacin + minocycline

C. Clofazimine + ofloxacin + clarithromycin

D. Ofloxacin + minocycline + clarithromycin

54.10 Which antileprotic drug suppresses lepra reaction

and reversal reaction as well:

A. Dapsone

B. Rifampin

C. Clofazimine

D. Minocycline

54.11 In the multidrug therapy of leprosy, rifampicin is given:

A. Daily

B. On alternate days

C. Weekly

D. Monthly

54.12 The following is true of multidrug therapy of leprosy except:

A. It has been highly successful in paucibacillary but not in multibacillary cases

B. Relapse rate is very low in both paucibacillary and multibacillary cases

C. No resistance to rifampin develops despite its use once a month

D. Prevalence of lepra reaction is not higher

compared to dapsone monotherapy

54.13 Currently, under the mass programme (WHO/NLEP),

the duration of multidrug therapy for multibacillary leprosy is:

A. Two years fixed duration for all cases

B. One year fixed duration for all cases

C. Two years or more till disease inactivity is attained

D. One year for cases with bacillary index 3 or

less and two years for cases with bacillary

index 4 or more

54.14 A single dose rifampin + ofloxacin + minocycline

treatment has been recommended for:

A. All cases of paucibacillary leprosy

B. All relapse cases of paucibacillary leprosy

C. Single skin lesion paucibacillary leprosy

D. None of the above

Ans: