>>>part 10
55.1 In addition to fungi, amphotericin B is active against the following pathogen:
A. Anaerobic bacteria
B. Giardia
C. Leishmania
D. Rickettsiae
55.2 The polyene antibiotics act by:
A. Inhibiting fungal cytochrome P450 enzyme
B. Binding to ergosterol and creating micropores in fungal cell membrane
C. Inhibiting fungal DNA synthesis
D. Disorienting microtubules in fungal cells
55.3 Amphotericin B is not effective in the following fungal disease:
A. Cryptococcosis
B. Histoplasmosis
C. Blastomycosis
D. Dermatophytosis
55.4 The most important toxicity of amphotericin B is:
A. Nephrotoxicity
B. Neurotoxicity
C. Hepatotoxicity
D. Bone marrow depression
55.5 The newer lipid formulations of amphotericin B differ
from the conventional formulation in the following respects except:
A. They are more efficacious
B. They produce milder acute reaction
C. They are less nephrotoxic
D. They produce milder anaemia
55.6 Indicate the antifungal antibiotic which is used intravenously
for systemic mycosis:
A. Griseofulvin
B. Nystatin
C. Amphotericin B
D. Hamycin
55.7 The drug of choice for monilial diarrhoea is:
A. Flucytosine
B. Nystatin
C. Natamycin
D. Ketoconazole
55.8 Griseofulvin is indicated in:
A. All types of tinea infection
B. Onychomycosis
C. Pityriasis versicolor
D. Both ‘B’ and ‘C’
55.9 Select the antifungal drug which is administered only by the oral route:
A. Amphotericin B
B. Ketoconazole
C. Griseofulvin
D. Tolnaftate
55.10 The most probable mechanism of action of imidazole antifungal drugs is:
A. They bind to ergosterol in fungal cell membrane and make it leaky
B. They interfere with ergosterol synthesis by fungi
C. They interfere with fungal mitosis
D. They block oxidative phosphorylation in fungi
55.11 Clotrimazole is used for the following conditions except:
A. Monilial diarrhoea
B. Monilial vaginitis
C. Otomycosis
D. Tinea cruris
55.12 Which antifungal agent is effective in both dermatophytosis
as well as systemic mycosis:
A. Amphotericin B
B. Griseofulvin
C. Clotrimazole
D. Ketoconazole
55.13 Adverse effects of ketoconazole include the following except:
A. Gynaecomastia
B. Oligozoospermia
C. Kidney damage
D. Menstrual irregularities
55.14 The following statement is true about ketoconazole except:
A. It is less toxic than amphotericin B
B. It produces a slower response than amphotericin
B in systemic mycosis
C. Given orally it is the first line treatment for vaginal candidiasis
D. It is not effective in fungal meningitis
55.15 Choose the azole antifungal drug which is used only topically:
A. Ketoconazole
B. Fluconazole
C. Itraconazole
D. Econazole
55.16 Fluconazole differs from ketoconazole in that:
A. It is not active by the oral route
B. It is a more potent inhibitor of drug metabolism
C. It is not effective in cryptococcal meningitis
D. It is unlikely to produce anti-androgenic side effects
55.17 Fluconazole offers the following advantage(s) over ketoconazole:
A. It is longer acting
B. Its absorption from stomach is not dependent on gastric acidity
C. It produces fewer side effects
D. All of the above
55.18 The following is applicable to itraconazole except:
A. It has largely replaced ketoconazole for treatment of systemic mycosis
B. It does not inhibit human steroid hormone synthesis
C. It is preferred for the treatment of fungal meningitis
D. It can interact with terfenadine to produce ventricular arrhythmias
55.19 Fluconazole is more effective than intraconazole in
the following systemic fungal disease:
A. Pulmonary histoplasmosis
B. Cryptococcal meningitis
C. Nonmeningeal blastomycosis
D. Disseminated sporotrichosis
55.20 The only azole antifungal drug which has some
activity against moulds like Aspergillus is:
A. Itraconazole
B. Fluconazole
C. Miconazole
D. Ketoconazole
55.21 Select the drug that is fungicidal and acts by inhibiting
fungal squalene epoxidase enzyme:
A. Ketoconazole
B. Terbinafine
C. Tolnaftate
D. Hamycin
55.22 The following drugs are effective in systemic mycosis except:
A. Terbinafine
B. Itraconazole
C. Ketoconazole
D. Fluconazole
55.23 The distinctive feature of terbinafine is:
A. It is highly effective in histoplasmosis
B. It can be used topically as well as orally for dermatophytosis
C. It inhibits Mucor and Aspergillus as well
D. Applied intravaginally it cures both candida as well as trichomonas vaginitis
55.24 The following are topical antifungal drugs except:
A. Ciclopirox olamine
B. Tolnaftate
C. Crotamiton
D. Terbinafine
Ans:
55.1 C 55.2 B 55.3D 55.4 A 55.5 A 55.6 C 55.7 B 55.8 B 55.9 C 55.10 B 55.11 A 55.12D 55.13 C 55.14 C 55.15D 55.16D 55.17D 55.18 C 55.19 B 55.20 A 55.21 B 55.22 A 55.23 B 55.24 C
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