56.1 Iodoxuridine is indicated in:
A. Herpes simplex keratitis
B. Herpes zoster
C. Chickenpox
D. All of the above
56.2 The high virus selectivity of acyclovir is due to:
A. Its preferential uptake by virus infected cells
B. Need of virus specific enzyme for its conversion to the active metabolite
C. Its action on virus directed reverse transcriptase which does not occur in noninfected cells
D. Both ‘A’ and ‘B’ are correct
56.3 Which of the following viruses is most susceptible to acyclovir:
A. Herpes simplex type I virus
B. Herpes simplex type II virus
C. Varicella-zoster virus
D. Epstein-Barr virus
56.4 What is true of acyclovir treatment of genital herpes simplex:
A. Topical treatment affords symptomatic relief in primary as well as recurrent disease
B. Oral therapy for 10 days affords symptomatic relief as well as prevents recurrences
C. Oral therapy for 10 days affords symptomatic relief but does not prevent recurrences
D. Continuous long-term topical therapy is recommended to prevent recurrences
56.5 Ganciclovir is preferred over acyclovir in the following condition:
A. Herpes simplex keratitis
B. Herpes zoster
C. Chickenpox
D. Cytomegalovirus retinitis in AIDS patients
56.6 Choose the correct statement about famciclovir:
A. It is active against acyclovir resistant strains of herpes simplex virus
B. It does not need conversion to an active metabolite
C. It is used orally to treat genital herpes simplex
D. It is the drug of choice for cytomegalovirus retinitis
56.7 Zidovudine inhibits the following virus/viruses:
A. Human immunodeficiency virus
B. Cytomegalovirus
C. Hepatitis B virus
D. Both 'A' and 'B'
56.8 Currently, monotherapy with zidovudine is recommended for:
A. Asymptomatic HIV positive subjects with CD4 cell count more than 200/μl
B. Asymptomatic HIV positive subjects with CD4 cell count less than 200/μl
C. HIV positive subjects with opportunistic infection
D. None of the above
56.9 Though the following drug reduces HIV titre, it is used
only to treat associated cytomegalovirus infection in
AIDS patients:
A. Didanosine
B. Foscarnet
C. Acyclovir
D. Saquinavir
56.10 The virus directed reverse transcriptase enzyme is inhibited by:
A. Amantadine
B. Zidovudine
C. Vidarabine
D. Acyclovir
56.11 The following anti-HIV drug should not be combined
with zidovudine because of mutual antagonism:
A. Stavudine
B. Lamivudine
C. Nevirapine
D. Ritonavir
56.12 Select the drug that is active against both HIV and
hepatitis B virus:
A. Lamivudine
B. Indinavir
C. Didanosine
D. Efavirenz
56.13 Antiretroviral treatment affords the following benefit(s) in HIV infection:
A. Increases CD4 leucocyte count
B. Reduces the incidence of opportunistic infections in AIDS patients
C. Increases survival time in AIDS patients
D. All of the above
56.14 A health worker got accidentally exposed to HIV infected
biological sample. Antiretroviral treatment will achieve the following in him:
A. Reduce the risk of contracting HIV infection
B. Rule out the possibility of contracting HIV infection
C. Prevent appearance of HIV seropositivity but not HIV infection in him
D. None of the above
56.15 Select the drug that acts by inhibiting HIV protease enzyme:
A. Zalcitabine
B. Efavirenz
C. Stavudine
D. Nelfinavir
56.16 Anti-HIV drug therapy is recommended in the following category of HIV exposed subjects:
A. HIV positive symptomatic patients with opportunistic infections
B. HIV positive asymptomatic subjects with CD4 cell count more than 400/μl
C. HIV positive asymptomatic subjects with CD4 cell count less than 200/μl
D. Both 'A' and 'C'
56.17 Antiretroviral therapy is not recommended in asymptomatic
HIV infected subjects with CD4 cell count more than 350/μl because of the following reason(s):
A. All antiretroviral drugs lose efficacy after some time
B. Adverse effects of antiretroviral drugs compromise the quality of life of asymptomatic
subjects
C. The treated subjects may produce and transmit drug resistant virus
D. All of the above
56.18 Select the drug which directly inhibits HIV-reverse
transcriptase without the need for intracellular
activation by phosphorylation:
A. Nelfinavir
B. Nevirapine
C. Stavudine
D. Didanosine
56.19 According to current guidelines, previously untreated
symptomatic HIV patients should be treated with:
A. Zidovudine alone
B. Zidovudine + zalcitabine
C. Zidovudine + indinavir
D. Any two nucleoside reverse transcriptase
inhibitors + one protease inhibitor
56.20 Indicate the drug(s) that is/are used to treat chronic hepatitis B:
A. Human interferon α
B. Lamivudine
C. Amantadine
D. Both 'A' and 'B'
56.21 Choose the correct statement(s) about retroviral protease inhibitors:
A. They act at an early step in HIV replication
B. They are more active in inhibiting HIV than zidovudine
C. They inhibit CYP3A4 and interact with many other drugs
D. Both 'B' and 'C' are correct
56.22 An AIDS patient treated with zidovudine + lamivudine
+ nelfinavir developed intolerable adverse effects. Then:
A. Dose of all three drugs should be reduced to half
B. All three drugs should be stopped or substituted simultaneously
C. The drugs should be stopped one by one
D. Two drugs should be stopped while continuing the third
56.23 The HIV titer of an AIDS patient was found to be
reduced but still detectable after 6 months of tripple
drug anti-HIV therapy. The best course of action in
this patient is:
A. Continue the same 3 drugs for another 3 months
B. Replace all 3 drugs with a set of another 3 drugs
C. Replace 2 drugs and continue one previously used drug
D. Replace one drug and continue two previously used drugs
56.24 Presently, the goal of antiretroviral therapy is:
A. Eradication of HIV from the body of the patient
B. Inhibit viral replication to undetectable levels
C. Restore immune competence of the patient to effective level
D. Both 'B' and 'C'
56.25 Indicate the anti-HIV regimen that is generally
reserved for advanced cases of AIDS or for repeated
treatment failures:
A. Two nucleoside reverse transcriptase inhibitors (NRTIs) + one protease inhibitor (PI)
B. Three NRTIs
C. Two NRTIs + one non-NRTI
D. One NRTI + one non-NRTI + one PI
56.26 The initial regimen for antiretroviral therapy of
previously untreated HIV patient consist of:
A. Two nucleoside reverse transcriptase inhibitors (NRTIs) + one protease inhibitor (PI)
B. Two NRTIs + one non-NRTI
C. Three NRTIs
D. Any of the above
56.27 Choose the correct statement about amantadine:
A. It is an antimetabolite used for viral infections
B. It prevents penetration of the virus into the host cell
C. It is used to protect high risk subjects during an influenza A2 epidemic
D. Concurrent administration of amantadine
prevents antibody response to influenza vaccine
56.28 The antiviral action of amantadine is exerted through:
A. Interaction with the viral M2 protein
B. Interaction with a virus directed thymidine kinase
C. Inhibition of a viral protease enzyme
D. Inhibition of viral RNA mediated DNA synthesis
56.29 What is true about human interferon α:
A. It is used to treat HIV infection
B. It is used to treat Kaposi‘s sarcoma in AIDS patients
C. It is curative for hepatitis B virus infection
D. It is active orally
Ans:
56.1 A 56.2D 56.3 A 56.4 C 56.5D 56.6 C 56.7 A 56.8D 56.9 B 56.10 B 56.11 A 56.12 A 56.13D 56.14 A 56.15D 56.16 C 56.17D 56.18 B 56.19D 56.20D 56.21D 56.22 B 56.23 B 56.24D 56.25D 56.26D 56.27 C 56.28 A 56.29 B