MCQs-Antimicrobial Drugst Part 11 I Pharmacology KD Tripathi mcqs part 57

57.1 Select the drug which is a causal prophylactic for both

falciparum and vivax malaria but is not used as

prophylactic on mass scale due to risk of severe

reaction in some individuals:

A. Mefloquine

B. Amodiaquine

C. Primaquine

D. Pyrimethamine

57.2 Erythrocytic schizontocide antimalarial drugs are

used as:

A. Suppressive prophylactic

B. Clinical curative

C. Radical curative for P.vivax

D. Both ‘A’ and ‘B’

57.3 The following drug is a causal prophylactic for

falciparum malaria and suppressive prophylactic for

vivax malaria:

A. Chloroquine

B. Mepacrine

C. Quinine

D. Proguanil

57.4 An adult male living in nonmalarious area has to visit

an area where chloroquine resistant P. falciparum is

prevalent. He is intolerant to mefloquine and his G-

6PD status is unknown. Select the drug that you will

prescribe for prophylaxis of malaria:

A. Primaquine

B. Doxycycline

C. Amodiaquine

D. Quinine

57.5 The total dose of chloroquine (base) for treatment of

an episode of malarial fever in a nonimmune adult is:

A. 1000 mg

B. 1500 mg

C. 2000 mg

D. 2500 mg

57.6 Recrudescence of malaria refers to recurrence of

malarial fever due to:

A. Reinfection of the patient by mosquito bite

B. Reinfection of blood by exoerythrocytic hypnozoites

C. Incomplete clearance of schizonts from blood

D. Any of the above

57.7 The following drug should be used only as clinical

curative but not as prophylactic in malaria:

A. Pyrimethamine + sulfadoxine

B. Proguanil

C. Primaquine

D. Mefloquine

57.8 If a drug is active against the preerythrocytic stage

of the malarial parasite it will be useful as a:

A. Suppressive prophylactic

B. Causal prophylactic

C. Clinical curative

D. Radical curative

57.9 Chemoprophylaxis of malaria is recommended for

the following category of subjects:

A. Residents of nonendemic areas

B. Residents of endemic areas

C. Travellers from nonendemic to endemic areas

D. Travellers from endemic to nonendemic areas

57.10 Indicate the drug that is a slow acting low efficacy

blood schizontocide that should not be used as a

clinical curative:

A. Proguanil

B. Chloroquine

C. Quinine

D. Mefloquine 

57.11 A patient of vivax malaria was treated with the

standard dose of chloroquine. After 6 weeks he

reported back with a relapse. Which drug will you

use to treat the relapse episode:

A. Chloroquine

B. Primaquine

C. Pyrimethamine + sulfadoxine

D. Mefloquine

57.12 Chloroquine resistant P. falciparum malaria can be

cured by the following drugs except:

A. Quinine

B. Pyrimethamine + sulfadoxine

C. Primaquine

D. Artesunate

57.13 Select the correct statement about primaquine:

A. It has no role in falciparum malaria

B. It is used as a gametocidal drug in falciparum malaria

C. It is combined with chloroquine to treatresistant P. falciparum infection

D. It is used to prevent recrudescence of falciparum malaria

57.14 Radical cure of vivax malaria should be attempted in:

A. Areas where only sporadic cases occur

B. Endemic areas with effective vector control

measures

C. Endemic areas not covered by vector control

D. Both ‘A’ and ‘B’ are correct

57.15 The following drug is a radical curative in vivax

malaria:

A. Quinine

B. Primaquine

C. Mefloquine

D. Chloroquine

57.16 The regimens recommended for treatment of chloroquine

resistant P.falciparum malaria in an adult

include the following except:

A. Quinine 10 mg/kg/8 hourly+ doxycycline 100 mg/day for 7 days

B. Quinine 10 mg/kg 3 times a day × 7 days

with pyrimethamine 75 mg + sulfadoxine

1500 mg on first day

C. Mefloquine 0.5 g daily for 7 days

D. Artemether 80 mg i.m./twice on first day

followed by once daily for 4 days

57.17 Chloroquine acts as:

A. Preerythrocytic schizontocide for both P.

falciparum and P. vivax

B. Erythrocytic schizontocide for both P. falciparum

and P. vivax

C. Exoerythrocytic schizontocide for P. vivax

D. Gametocidal for P. falciparum 

57.18 In addition to malarial parasite, chloroquine is active

against:

A. Microfilariae

B. Trichomonas vaginalis

C. Entamoeba histolytica

D. Dermatophytes

57.19 Which of the following drugs is suitable for treatment

of malaria during pregnancy:

A. Quinine

B. Chloroquine

C. Pyrimethamine

D. Primaquine

57.20 Chloroquine is indicated in the following disorders

except:

A. Rheumatic fever

B. Discoid lupus erythematosus

C. Photogenic skin reactions

D. Lepra reaction

57.21 Choose the drug whose single oral dose affords

clinical cure of uncomplicated malaria caused by

chloroquine sensitive/resistant P.falciparum as well

as P. vivax:

A. Quinine

B. Mefloquine

C. Artesunate

D. Proguanil

57.22 The following is true of mefloquine:

A. P. falciparum does not develop resistance to

mefloquine

B. Concurrent use of β blockers with mefloquine

is contraindicated

C. Neuropsychiatric reactions are the most

important adverse effects of mefloquine

D. All of the above

57.23 The drug of choice for cerebral malaria due to

P. falciparum is:

A. Quinine

B. Mefloquine

C. Chloroquine

D. Pyrimethamine + Sulfadoxine

57.24 Clinical applications of quinine include the following

except:

A. Uncomplicated chloroquine resistant malaria

B. Cerebral malaria

C. To induce abortion

D. Nocturnal leg cramps

57.25 Intravenous injection of quinine produces:

A. Rise in blood pressure

B. Neuromuscular block

C. Hyperglycaemia

D. Hypoglycaemia

57.26 The following is true of quinine:

A. It has a longer elimination half-life than

chloroquine

B. It is not to be used for prophylaxis of malaria

C. It is not active against P. vivax

D. It should not be used along with sulfa-pyrimethamine

57.27 Select the drug/combination that you will prescribe

as a prophylactic to a resident of non-endemic area

who got posted for 6 months to an endemic area with

low degree chloroquine resistance among P. falciparum:

A. Quinine

B. Proguanil + Chloroquine

C. Pyrimethamine + Sulfadoxine

D. Artemisinin

57.28 The fastest acting schizontocidal drug among the

following is:

A. Artemether

B. Mefloquine

C. Chloroquine

D. Proguanil

57.29 Proguanil is not used as a clinical curative in malaria

because:

A. Its schizontocidal action is slow

B. Resistance to proguanil is widespread

C. It is more toxic than chloroquine

D. All of the above are correct

57.30 Pyrimethamine + sulfadoxine should be used as a:

A. Clinical curative in areas with chloroquine

resistant malaria

B. Clinical curative in areas without chloroquine

resistance among P. falciparum

C. Prophylactic in areas with or without chloroquine

resistance

D. All of the above

57.31 Sulfadoxine-pyrimethamine combination is used as

clinical curative but is not recommended for prophylaxis

of malaria because of:

A. Risk of megaloblastic anaemia due to pyrimethamine

B. Risk of severe dermatological reactions to sulfadoxine

C. Need for daily administration of the drug

D. Slow schizontocidal action of the drug

 

57.32 The following antimalarial drug is more active against

pre-and exoerythrocytic stages of the malarial

parasite than against the erythrocytic stage:

A. Proguanil

B. Primaquine

C. Pyrimethamine

D. Halofantrine

57.33 The most important risk in the use of primaquine is

the occurrence of the following reaction in certain recipients:

A. Ventricular arrhythmia

B. Agranulocytosis

C. Haemolysis

D. Anaphylaxis

57.34 Use of the following antimalarial drug carries high risk

of adverse effect in subjects with G-6-PD deficiency:

A. Pyrimethamine

B. Artemisinin

C. Primaquine

D. Mefloquine

57.35 Indicate the drug that can be used as an alternative

to primaquine for radical cure of vivax malaria:

A. Atovaquone

B. Bulaquine

C. Tetracycline

D. Proguanil

57.36 Recrudescences attending 3 day artesunate therapy

of chloroquine resistant falciparum malaria can be

prevented by combining it with a single dose of:

A. Quinine

B. Primaquine

C. Tetracycline

D. Mefloquine 

57.37 Use of artemisinin derivatives is restricted to treatment

of multidrug resistant falciparum malaria because:

A. Wide spread use for all cases of malaria may

foster development of resistant strains

B. They are not active against P.vivax

C. They are more toxic than quinine

D. All of the above are correct

57.38 Choose the antimalarial drug effective against multidrug

resistant P. falciparum, which rapidly terminates

an attack of malarial fever, but has a short duration

of action, so that recrudescence is common:

A. Proguanil

B. Mefloquine

C. Amodiaquine

D. Artemisinin 

Ans:

57.1 C 57.2D 57.3D 57.4 B 57.5 B 57.6 C 57.7 A 57.8 B 57.9 C 57.10 A 57.11 A 57.12 C 57.13 B 57.14D 57.15 B 57.16 C 57.17 B 57.18 C 57.19 B 57.20 A 57.21 B 57.22 C 57.23 A 57.24 C 57.25D 57.26 B 57.27 B 57.28 A 57.29 A 57.30 A 57.31 B 57.32 B 57.33 C 57.34 C 57.35 B 57.36D 57.37 A 57.38D