MCQs-Antimicrobial Drugst Part 12 I Pharmacology KD Tripathi mcqs part 58

58.1 Choose the correct statement(s) about metronidazole:

A. It is a first line drug for amoebic dysentery as well as amoebic liver abscess

B. It affords the most rapid symptom relief in amoebic dysentery

C. It is the most effective drug in eradicating amoebic cysts from the colon

D. All of the above

58.2 In addition to amoebiasis, metronidazole is used for:

A. Roundworm infestation

B. Hookworm infestation

C. Kala-azar

D. Giardiasis

58.3 Metronidazole is selectively active against anaerobic

organisms because:

A. Aerobes have an active transport mechanism to pump it out of their cell

B. Only anaerobes reduce it to generate the reactive nitro radical

C. It is rapidly inactivated in the presence of oxygen

D. It binds to DNA of anaerobes with high affinity

58.4 Select the drug which is used to treat antibiotic

associated pseudomembranous enterocolitis and is

a component of anti-H.pylori triple drug regimen:

A. Amoxicillin

B. Vancomycin

C. Metronidazole

D. Clotrimazole

58.5 Metronidazole is used in peridontal abscess because

of activity against:

A. Entamoeba histolytica

B. Giardia lamblia

C. Anaerobic bacilli

D. Aerobic gram positive cocci

58.6 The following precaution should be advised to the

patient while prescribing metronidazole:

A. To avoid driving

B. To get leucocyte count checked every second day

C. To avoid fatty/fried food

D. To avoid alcoholic beverages

58.7 In addition to having antiamoebic activity, tinidazole inhibits:

A. Anaerobic bacilli

B. Aerobic bacilli

C. Gram positive cocci

D. Gram negative cocci

58.8 Tinidazole differs from metronidazole in that:

A. It is not active against anaerobic bacteria

B. It has a broader spectrum of activity

C. It has a longer elimination half life

D. It has better oral absorption

58.9 The distinctive feature of secnidazole is:

A. It is not absorbed after oral ingestion

B. It is recommended for single dose treatment

of intestinal amoebiasis

C. It is effective in intestinal but not in hepatic amoebiasis

D. It is effective in both trichomonas as well as monilial vaginitis

58.10 Indicate the drug that is not effective in amoebiasis

A. Ornidazole

B. Mebendazole

C. Satranidazole

D. Secnidazole

58.11 Emetine is now used only as a reserve drug for

amoebiasis because:

A. It is less effective than metronidazole

B. It produces a slower response than metronidazole

C. It has cardiotoxic potential

D. It is not effective in extraintestinal amoebiasis

58.12 The following drug is effective in hepatic amoebiasis

but not in intestinal amoebiasis:

A. Chloroquine

B. Emetine

C. Tetracycline

D. Diloxanide furoate

58.13 Choose the most effective drug for mild intestinal

amoebiasis and asymptomatic cyst passers:

A. Metronidazole

B. Emetine

C. Quiniodochlor

D. Diloxanide furoate

58.14 Prolonged use of the following drug has been implicated

in the causation of subacute myelo-optic neuropathy (SMON):

A. Diloxanide furoate

B. Iodochlorhydroxyquin

C. Emetine

D. Furazolidone

58.15 The following antiamoebic drug should not be used in

children because of risk of causing blindness:

A. Quiniodochlor

B. Diloxanide furoate

C. Tinidazole

D. Secnidazole

58.16 Choose the drug that can be used orally for intestinal

amoebiasis, intravaginally for trichomonas vaginitis

and topically for dermatophytosis:

A. Quiniodochlor

B. Furazolidone

C. Ornidazole

D. Hamycin

58.17 After treating intestinal amoebiasis with metronidazole,

a course of diloxanide furoate is often advised to:

A. Cure any subclinical hepatic involvement

B. Suppress the symbiotic intestinal flora

C. Eradicate luminal cyst forming trophozoites

D. Both ‘B’ and ‘C’ are correct

58.18 Tetracycline is indicated in the following form(s) of

amoebic infection:

A. Acute amoebic dysentery

B. Chronic intestinal amoebiasis

C. Amoebic liver abscess

D. All of the above

58.19 Select the drug which is active against a variety of

diarrhoea producing organisms like Giardia, Shigella,

Salmonella as well as S. typhi and Trichomonas

vaginalis, but is not a first line treatment for any of these:

A. Metronidazole

B. Mepacrine

C. Cotrimoxazole

D. Furazolidone\

58.20 The following drug is used for oral treatment of

trichomonas vaginitis:

A. Diiodohydroxyquin

B. Tinidazole

C. Clotrimazole

D. Natamycin

58.21 The drug of choice for Kala azar is:

A. Pentamidine

B. Amphotericin B

C. Sodium stibogluconate

D. Ketoconazole

58.22 Pentamidine should be used to treat Kala azar only

when sodium stibogluconate has failed or is not

tolerated because:

A. It achieves lower cure rates

B. It is more toxic

C. It requires a longer course of treatment

D. Relapses are more common with it

58.23 What is true about use of amphotericin B in kala azar:

A. It is currently the drug of choice

B. It is more effective than ketoconazole

C. It is indicated only in cases not responding to

sodium stibogluconate

D. Both 'B' and 'C' are correct

58.24 Pentamidine is a first line drug for the following disease:

A. Toxoplasmosis

B. Pneumocystis carinii pneumonia

C. Actinomycosis

D. Leishmaniasis

58.25 Select the antimetabolite which is toxic to Leishmania

but not to mammalian cells:

A. Allopurinol

B. Cytarabine

C. 6-Mercaptopurine

D. 6-Thioguanine

58.26 Leishmania donovani is susceptible to certain antifungal

drugs because both fungi and Leishmania:

A. Utilise purine salvage pathway

B. Utilise similar glycolytic mechanisms

C. Have similar topoisomerase II enzyme

D. Have ergosterol in their cell membranes

Ans:

58.1 A 58.2D 58.3 B 58.4 C 58.5 C 58.6D 58.7 A 58.8 C 58.9 B 58.10 B 58.11 C 58.12 A 58.13D 58.14 B 58.15 A 58.16 A 58.17 C 58.18 B 58.19D 58.20 B 58.21 C 58.22 B 58.23D 58.24 B 58.25 A 58.26D