MCQs-Antimicrobial Drugst Part 13 I Pharmacology KD Tripathi mcqs part 59

59.1 As an anthelmintic mebendazole has the following advantages except:

A. It is active against most intestinal helminths

B. It is very well tolerated

C. Single dose cures roundworm and hookworm infestation

D. It does not require predrug fasting or postdrug purging

59.2 The most probable mechanism of action of

mebendazole is:

A. Depolarization of membrane and spastic

paralysis of the worm

B. Hyperpolarization of membrane and flaccid

paralysis of the worm

C. Loss of intracellular microtubules and

inhibition of glucose uptake in the worm

D. Tegument damage and leakage of contents

of the worm

59.3 Albendazole is less effective than mebendazole in

the following helminthic infestation:

A. Hydatid disease

B. Trichuriasis

C. Strongyloidosis

D. Ascariasis

59.4 The following helminthic disease can be treated by

albendazole but not by mebendazole:

A. Hookworm infestation

B. Threadworm infestation

C. Trichuriasis

D. Neurocysticercosis

59.5 The following anthelmintic acts as a cholinergic

agonist in the nematodes and causes spastic

paralysis of the worms:

A. Piperazine

B. Pyrantel pamoate

C. Mebendazole

D. Thiabendazole

59.6 Select the condition for which 3 days treatment with

pyrantel pamoate is recommended in place of single

dose therapy for others:

A. Ascariasis

B. Ancylostomiasis

C. Necatoriasis

D. Enterobiasis

59.7 Piperazine antagonises the anthelmintic action of

the following drug:

A. Pyrantel pamoate

B. Mebendazole

C. Albendazole

D. Niclosamide

59.8 Anthelmintic action of piperazine is due to:

A. Interference with ATP generation in the worm

B. Blockade of glucose uptake by the worm

C. Hyperpolarization of nematode muscle by

GABA agonistic action

D. Depolarization of nematode muscle by

activating nicotinic receptors

59.9 The following anthelmintic has been found to be safe

during pregnancy:

A. Thiabendazole

B. Piperazine

C. Albendazole

D. Pyrantel pamoate

59.10 A child has been brought with intestinal obstruction

due to clumping of roundworms. Select the

anthelmintic which administered by intragastric tube

can relax the ascarids and relieve the obstruction:

A. Levamisole

B. Mebendazole

C. Pyrantel pamoate

D. Piperazine

59.11 The following is true of levamisole except:

A. A single dose cures over 90% cases of round

worm infestation

B. It is more effective against Necator americanus

than against Ancylostoma duodenale

C. It has immunomodulating action

D. Its prolonged use causes severe reactions

59.12 Thiabendazole is rarely used now because:

A. It frequently produces incapacitating side

effects

B. It produces lower cure rates in intestinal

helminthiasis than mebendazole or albendazole

C. It needs pretreatment fasting and post treatment

purgative

D. It is not active against roundworm and hookworm

59.13 Drug/drugs effective in filariasis include:

A. Ivermectin

B. Albendazole

C. Diethyl carbamazine citrate

D. All of the above

59.14 Diethyl carbamazine citrate has the following action

in filariasis:

A. Rapidly kills adult filarial worms and stops

production of microfilariae

B. Kills circulating microfilariae

C. Kills microfilariae present in nodules and serous fluids

D. Promotes phagocytosis of circulating microfilariae

59.15 The effects of diethyl carbamazine citrate in filariasis

include the following except:

A. Rapid symptomatic relief in acute filarial

attack

B. Renders filarial patients noninfective to mosquitoes

C. Prolonged treatment induces regression of

filarial elephantiasis

D. Prolonged treatment may achieve radical

cure by killing adult filarial worms lodged in

lymphatics 

59.16 The drug of choice for tropical eosinophilia is:

A. Carbamazepine

B. Diethyl carbamazine citrate

C. Carbetapentane

D. Clomiphene citrate

59.17 Select the drug that is used orally to treat scabies:

A. Permethrin

B. Ivermectin

C. Praziquantel

D. Crotamiton

59.18 Which anthelmintic drug acts through a specific glutamate

gated Cl– ion channel found only in nematodes:

A. Ivermectin

B. Niclosamide

C. Pyrantel pamoate

D. Praziquantel

59.19 What is true of ivermectin:

A. It is the most effective drug for strongyloidosis

B. It is the drug of choice for onchocerciasis

C. It can be used to treat pediculosis

D. All of the above

59.20 Praziquantel is preferred over niclosamide for Taenia

solium infestation because:

A. It achieves higher cure rates

B. It produces fewer side effects

C. It does not lead to digestion of worm and

kills encysted larvae, so that chances of

cysticercosis are minimized

D. Both ‘A’ and ‘B’ are correct

59.21 A saline purgative is recommended following:

A. Niclosamide for tapeworm infestation

B. Mebendazole for roundworm infestation

C. Pyrantel pamoate for hookworm infestation

D. Albendazole for whipworm infestation 

 

59.22 For the treatment of Hymenolepis nana infestation,

praziquantel has the following advantage(s) over

niclosamide:

A. It is better tolerated

B. It requires single dose treatment against 5

days treatment with niclosamide

C. A purgative is required after niclosamide

but not after praziquantel

D. All of the above

59.23 The drug of choice for neurocysticercosis is:

A. Albendazole

B. Niclosamide

C. Praziquantel

D. Ivermectin

59.24 Praziquantel is effective against the following

helminth(s):

A. Taenia saginata

B. Diphyllobothrium latum

C. Schistosomes

D. All of the above

Ans :

59.1 C 59.2 C 59.3 B 59.4D 59.5 B 59.6 C 59.7 A 59.8 C 59.9 B 59.10D 59.11 B 59.12 A 59.13D 59.14D 59.15 C 59.16 B 59.17 B 59.18 A 59.19D 59.20 C 59.21 A 59.22 B 59.23 A 59.24D