MCQs-Chemotherapy of Neoplastic Diseases Part 1 I Pharmacology KD Tripathi mcqs part 60

60.1 Which of the following neoplastic diseases is almost

curable by chemotherapy:

A. Bronchogenic carcinoma

B. Choriocarcinoma

C. Malignant melanoma

D. Colorectal carcinoma

60.2 The following anticancer drug has high emetogenic

potential:

A. Vincristine

B. Chlorambucil

C. 6-Mercaptopurine

D. Cisplatin

60.3 The following is true of cancer chemotherapy:

A. Anticancer drugs increase the risk of developing

leukaemias and lymphomas several

years later

B. All anticancer drugs are highly emetogenic

C. Growth fraction of cancers is higher than

any nomral tissue of the body

D. All of the above are correct

 

60.4 Anticancer drugs weaken host defence by:

A. Damaging respiratory and gut epithelia

B. Inducing granulocytopenia

C. Altering resident microbial flora

D. Both 'A' and 'B' are correct

60.5 Practically all antineoplastic drugs can produce the

following toxic effects except:

A. Depression of leucocyte count

B. Mucositis

C. Cardiomyopathy

D. Oligozoospermia

60.6 Alkylating agents exert cytotoxic action by inducing:

A. Breakage of DNA strand

B. Cross linking of DNA strands

C. Abnormal pairing of purine and pyrimidine bases

D. All of the above

60.7 The following is true of cyclophosphamide except:

A. It is highly reactive and a vesicant on contact

B. It is a prodrug

C. It has marked immunosuppressant property

D. It frequently causes alopecia and cystitis

60.8 The most important target of action of chlorambucil is:

A. Myeloid tissue

B. Lymphoid tissue

C. Neural tissue

D. Skin

60.9 Methotrexate has the following attributes except:

A. It is cell cycle specific and kills cells in the S phase

B. Its toxicity primarily affects bone marrow and epithelial structures

C. Folic acid reverses its toxic effects

D. It is the drug of choice for choriocarcinoma

60.10 The following antineoplastic drug is a mitotic

inhibitor and causes metaphase arrest:

A. Busulfan

B. Vincristine

C. Cytarabine

D. Procarbazine

60.11 Vinca alkaloids exert antitumor activity by:

A. Activating topoisomerase II to cause breaks

in DNA strands

B. Crosslinking DNA strands

C. Inhibiting DNA mediated RNA synthesis

D. Inhibiting polymerization of tubulin to form

intracellular microtubules

60.12 The following cytotoxic drug acts by inhibiting depolymerization

of tubulin and thus producing abnormal

arrays of microtubules:

A. Paclitaxel

B. Vinblastine

C. Etoposide

D. Mitoxantrone

60.13 Vincristine differs from vinblastine in the following respect(s):

A. Its prominent adverse effect is neuropathy

B. It frequently produces alopecia

C. It does not significantly depress bone marrow

D. All of the above

60.14 What is true of docetaxel:

A. It is used as a reserve drug for refractory

breast and ovarian cancer

B. It is a selective estrogen receptor modulator

used for breast cancer

C. It is effective only in estrogen receptor

positive breast cancer

D. Both 'B' and 'C' are correct

60.15 Choose the correct statement about topotecan:

A. It is a DNA topoisomerase I inhibitor which

causes single strand DNA breaks

B. It is a cell cycle specific anticancer drug

C. It is a COMT-inhibitor used in advanced

parkinsonism

D. Both 'A' and 'B' are correct

60.16 The characteristic toxicity of doxorubicin is:

A. Kidney damage

B. Liver damage

C. Cardiomyopathy

D. Pulmonary fibrosis

60.17 Thioguanine differs from mercaptopurine in that:

A. It is not metabolized by xanthine oxidase

B. It does not cause hyperuricemia

C. Its dose need not be reduced when allopurinol

is given concurrently

D. Both ‘A’ and ‘C’ are correct

60.18 Patients treated with the following anticancer drug

are likely to develop a disulfiram like reaction on

taking alcohol:

A. Dacarbazine

B. Procarbazine

C. Melphalan

D. Hydroxyurea

60.19 The following is true about use of prednisolone in

malignant diseases except:

A. It is curative in acute childhood leukaemia

B. It is used in Hodgkin’s disease

C. It controls hypercalcaemia in patients with

bony metastasis

D. It affords symptomatic relief in most cancer

patients

60.20 The following does not apply to cancer chemotherapy:

A. Each treatment with a cytotoxic drug kills a

constant number of malignant cells

B. Drugs are generally used at maximum

tolerated doses

C. The same regimen which is palliative for a

large solid tumour may be curative after

surgical removal of the tumour

D. Combination regimens using several drugs

in succession are superior to single drug

used continuously

60.21 Select the cell cycle nonspecific antineoplastic drug:

A. Vincristine

B. Bleomycin

C. Methotrexate

D. 5-Fluorouracil

60.22 Mesna is administered with cyclophosphamide and

ifosphamide to:

A. Potentiate their cytotoxic action

B. Retard their renal excretion

C. Block their emetic action

D. Ameliorate cystitis caused by them

60.23 Biological response modifiers like GM-CSF are used

in conjunction with anticancer drugs for the following

purpose(s):

A. To enhance antitumour activity of the drug

B. To prevent hypersensitivity reactions to the drug

C. To hasten recovery from drug induced myelosuppression

D. Both ‘A’ and ‘C’ are correct

60.24 What is true of thalidomide:

A. It exerts antitumour activity in some solid

malignant tumours

B. It ameliorates cancer associated cachexia

C. It exerts antileprotic action

D. All of the above

Ans:

60.1 B 60.2 D 60.3 A 60.4 D 60.5 C 60.6 D 60.7 A 60.8 B 60.9 C 60.10 B 60.11 D 60.12 A 60.13 D 60.14 A 60.15 D 60.16 C 60.17 D 60.18 B 60.19 A 60.20 A 60.21 D 60.22 D 60.23 C 60.24 B