MCQs - Biochemistry part 2

Part 1 👈👈

101. One of the following is oxidative pathway of glucose

(a) Gluconeogenesis

(b) Hexose mono phosphate shunt

(d) Lipogenesis

102. Generation of ATP during citric acid cycle is

(a) 8 (b) 22

(c) 24 (d) 30

103. Glycolysis reaction is regulate by catalyze the irreversible reaction by all of the following enzyme except

(a) Hexokinase

(b) Phosphofructokinase

(d) Phosphoglycerate kinase

104. The inhibition of glycolysis by oxygen is known as

(a) Crabtree effect

(b) Pasteur effect

(d) Krebs effect

105. In citric acid cycle citrate is convertinged in to isocitrate by

(a) Aconitase

(b) Isocitrate dehydrogenase

(d) Succinate dehydrogenase

106. In tricarboxylic acid cycle citrate synthase enzyme is inhibited by

(a) ADP

(b) AMP

(d) Succinyl Co-A

107. The enzymes of tricarboxylic acid cycle are located in

(a) Cytosol

(b) Mitochondrial matrix

(d) Liver

108. All of the following are precursors for gluconeogenesis

except

(a) Lactate

(b) Pyruvate

(c) Acetyl Co-A

(d) Glycerol

109. Gluconeogenesis is regulated by

(a) ACTH

(b) Glucagon

(d) Insulin

110. Glycogen synthesis is increased in one of the following conditions:

(a) If insulin level is increased

(b) If glucagon level is increased

(d) If glucose level is increased

111. Van Gierke’s disease occurs because of

(a) Glucose level is decreased

(b) Glucagon level is decreased

(c) Glycogen accumulates in hepatocytes and renal cells

(d) Lactic acid level is increased

112. In hexose mono phosphate shunt glucose 6-phosphate is converted in to 6 phosphogluconolactone by

(a) Glucose 6-Phosphate dehydrogenase

(b) Transketolase

(d) Phosphogluconate dehydrogenase

113. Uronic acid pathway is concerned with synthesis of

(a) Vitamin A (b) Vitamin D

(c) Vitamin C (d) Glucose

114. The process of shifting of hydrogen atom from one carbon atom to another to produce enediols is known as

(a) Anomers

(b) Epimers

(d) Tautomerization

115. Krebs Cycle is known as amphibolic because

(a) Catabolic in nature

(b) Anabolic in nature

(c) Both anabolic and catabolic in nature

(d) Either anabolic or catabolic in nature

116. Lyase means

(a) Enzymes specialized in the addition or removal of water, ammonia, etc.

(b) Enzymes that brings about hydrolysis of various compound

(d) Enzymes involved in all the isomerization reaction

117. Multienzyme complexes means

(a) It is made up of a single polypeptide

(b) Some of the enzymes which possess more than one polypeptide chain

(c) Possessing specific site to catalyse different reaction in a sequence

(d) Enzymes made up of apoenzyme and coenzyme

118. Hexokinase is classified as a

(a) Oxidoreductases enzyme

(b) Transferases enzyme

(d) Lyases enzyme

119. Most of the enzymes of the higher organism show optimum activity around

(a) pH 1–2

(b) pH 10–11

(c) pH 6–8

(d) pH 4–6

120. Thiamin pyrophosphate is derived from

(a) Thyroxine

(b) Thiamine

(d) Niacin

121. As per IUB enzyme activity is expressed in

(a) Micromol

(b) Katal

(d) Mcrogram

122. Serum glutamate pyruvate transminase is used for diagnose of

(a) Hepatitis

(b) Acute pancreatics

(d) Rickets

123. For cancer of prostate gland one of the following enzymes is used

(a) Amylase

(b) Alkaline phosphate

(c) Acid phosphate

(d) Aldolase

124. Indole ring is present in ____amino acid

(a) Tyrosine

(b) Proline

(c) Tryptophan

(d) Lysine

125. Gaucher’s disease occurs due to the deficiency of

(a) Ceramidase

(b) Hexosaminidase

(d) β Glucosidase

126. One of the following hormones decreases the cholesterol synthesis

(a) Insulin

(b) Thyroxine

(c) Glucagon

(d) Growth hormone

127. The protein component of lipoprotein is known as

(a) Chylomicron

(b) Apoprotein

(d) None of the above

128. According to the Frederickson’s classification of hyperliporoteinemias in Type IV

(a) Increased IDL level

(b) Increased LDL level

(c) Increased VLDL level

(d) Increased HDL level

129. In HDL ___________ of triacylglycerol is present.

(a) 88% (b) 55%

130. The two products in the β-oxidation of odd chain fatty

acids are

(a) Acetyl CoA and malonyl CoA

(b) Propionyl CoA and acyl CoA

(d) Propionyl CoA and acetyl CoA

131. Hypocholesterolemia is observed in the disorder

(a) Diabetes mellitus

(b) Thyrotoxicosis

(d) Nephrotic syndrome

132. One of the following amino acids contains hydroxyl group:

(a) Threonine

(b) Leucine

(d) Glutamine

133. Acidic amino acid is

(a) Lysine

(b) Arginine

(d) Glutamic acid

134. DNA and RNA differ in their structure:

(a) DNA contains Cytosine and RNA contains Adenine

(b) RNA contains Adenine and RNA contains Cytosine

(c) DNA contains Thymine and RNA contains Uracil

(d) RNA contains Guanine and RNA contains Adenine

135. In DNA structure width of double helix is

(a) 5 nm (b) 8 nm

136. Structure of polydeoxyribo- nucleotide segment is held by

(a) Peptide bonds

(b) Phospho bonds

(c) Phosphodiester bonds

(d) Amide bond

137. In DNA structure aAdenine makes the hydrogen bond only with

(a) Thiamine

(b) Guanine

(d) Uracil

138. In Z-DNA confirmation of DNA helix the number of base pairs present in each turn is

(a) 10

(b) 11

(c) 12

(d) 13

139. The sugar present in RNA is

(a) Ribose (b) Deoxyribose

140. In RNAs cellular composition of ribosomal RNA is

(a) 5–10% (b) 10–20%

(c) 50–80% (d) 20–50%

141. rRNA function is to

(a) Transfer genetic information from genes to ribosomes

(b) Provide structural framework for ribosomes

(d) Involve in the selection of protein for export

142. Which of the following enzymes is NADPH dependent?

(a) Malic enzyme

(b) HMG CoA reductase

(d) Tyramine dehyrogenase

143. By the non-oxidative deamination process enzyme

histidase act on histidine to convert in

(a) Threonine (b) Pyruvate

(c) Urocanate (d) Homoserine

144. Oxidative amination mostly takes place in

(a) Liver and kidney

(b) Liver and intestine

(d) Brain

145. In transamination process all transaminase require____ co-enzyme.

(a) Lipoic acid

(b) TPP

(d) PLP

146. Urea cycle is known as

(a) Embden–Meyerhof pathway

(b) Krebs–Henseleit cycle

(d) Kurt Henseleit cycle

147. Tocopherols prevents the oxidation of

(a) Vitamin D

(b) Vitamin A

(d) Vitamin B12

148. For the synthesis of creatine all of the following amino acids are required except

(a) Glycine

(b) Arginine

(c) Cysteine

(d) Methionine

149. Hypervitaminosis of vitamin A causes

(a) Xeropthalmia

(b) Pernicious anemia

(d) Dermatitis, loss of hair

150. Storehouse of ammonia in biological system is

(a) Glutamine

(b) Glutamate

(d) Urea

151. Lesch–Nyhan syndrome occurs due to deficiency of which enzyme?

(a) PRPP synthetase

(b) Xanthine oxidase

(c) HGPRT

(d) Glucose-6-phosphatase

152. Orotic aciduria can be treated by a diet rich in

(a) Adenine (b) Guanine

(c) Uridine (d) All of the above

153. Menke’s disease is due deficiency of which of the following?

(a) Iron

(b) Copper

(d) Sodium

154. Which is the storage form of iron?

(a) Ferritin

(b) Hemosiderin

(c) Both (a) and (b)

(d) None of the above

155. Krebs–Henseleit cycle occurs in

(a) Mitochondria

(b) Cytosol

(c) Both (a) and (b)

(d) Kidney

156. Citrullinemia is due to defect in which of the following enzyme?

(a) Carbamoyl phosphatase synthase

(b) Arginase

(d) Arginosuccinate synthase

157. Which amino acid is the precursor of melanine?

(a) Alanine (b) Tyrosine

158. Hyperlipoproteinemia type III is due to elevated plasma

level of which of the lipoproteins?

(a) LDL (b) VLDL

(c) IDL (d) Chylomicrone

159. Jamaican vomiting sickness disease is due to

(a) Hypoglycin C

(b) Haemoglobin

(c) Hypoglycin A

(d) Both (a) and (b)

160. Krabbe’s disease occurs due to defect in

(a) β-glucosidase

(b) β-galactocidase

(d) Hexosaminidases A

161. HMP shunt occurs in

(a) Mitochondria

(b) Cytosol

(d) None of the above

162. The reaction catalysed by hexokinase in glycolysis isbdependent on

(a) ATP

(b) Mg+

(c) Both (a) and (b)

(d) ADP

163. In Krebs cycle oxalosuccinate is converted to-ketoglutarate by which enzyme?

(a) -ketoglutarate dehydrogenase

(b) Isocitrate dehydrogenase

(d) Aconitase

164. Fluroacetate is the inhibitor of which enzyme in Krebs cycle?

(a) -ketoglutarate dehydrogenase

(b) Isocitrate dehydrogenase

(d) Aconitase

165. Cori’s disease is due to defect in which of the following enzyme?

(a) Glucose-6-phosphatase

(b) Amylo- -1,6-glucosidase

(d) Liver glycogen phosphorylase

166. What is the starting material of retinol?

(a) Butyraldehyde and formic acid

(b) Beta-ionone and methylvinyllactone

(d) Beta -ionone and methyl lactone

167. What is the starting material of pantothenic acid?

(a) Ribose

(b) Beta ionone and methyl lactone

(d) Formaldehyde and isobutyraldehyde

168. According to the chemical and biological classifications of fatty acids, we can classify palmitic acid as:

(a) Monounsaturated and essential

(b) Polyunsaturated and essential

(d) Saturated and non- essential

169. A premature baby, shortly after birth, presents with rapid breathing, intercostal retractions, and grunting

sound while breathing. A blood gas analysis reveals low oxygen and acidosis. A diagnosis of respiratory distress syndrome is quickly made. This syndrome is seen in newborns with immature lungs whose pneumocytes do not synthesize enough:

(a) Phosphatidyl choline

(b) Phosphatidyl inositol

(d) Sphingomyelin

170. The following compounds are phospholipids:

(a) Lecithin and sphingomyelin

(b) Plasmalogens and cerebrosides

(d) Glycerol and gangliosides

171. Name the enzymes involved in conversion of oxaloacetate to -ketoglutarate

(a) Isocitrate dehydrogenase

(b) Fumarase

(d) Thiolase

172. Which kind of enzymes catalyses the activation or inactivation of other proteins and enzymes by phosphorylation of specific amino acid residues in the

protein that acts as substrate:

(a) Cyclases (b) Kinases

173. This carbohydrate acts as lubricant of synovial fluid and

contributes to tensile strength and elasticity of cartilages and tendons. It is also an important component of skin.

(a) Cellulose (b) Glycogen

174. It is the most important polysaccharide in human diet:

(a) Heparine (b) Starch

175. In which form glucose is stored in muscle and liver?

(a) Cellulose (b) Glycogen

176. The compound 5,7,8 trimethyltocol is commonly known as ..

(a) α-tocopherol (b) ß-tocopherol

177. L-amino acid dehydrogenase is an enzyme that can catalyse the oxidation of different L-amino acids. It cannot catalyse the oxidation of D-amino acids or other L-compounds. Based on these characteristics we

can say that this enzyme shows:

(a) Absolute specificity over substrate

(b) Allosteric regulation

(c) Relative specificity over substrate

(d) Specificity of action

178. Inactive precursors of some enzymes that are activated through hydrolysis reactions are called:

(a) Apoenzyme

(b) Holoenzymes

(d) Zymogens

179. These enzymes have different structure but the same catalytic function. Frequently they are oligomers made from different polypeptide chains. These enzymes are called:

(a) Allosteric enzymes

(b) Isozymes

(d) Proenzymes

180. The necessary coenzyme for transamination reactions is

(a) Aminotransferases

(b) FAD

(d) FMN

181. In glucose metabolism, name the enzymes catalysing the following step: Conversion of glucose to glucose-6-phosphate?

(a) Hexokinase

(b) Glucokinase

(d) Phosphofructokinase

182. The amino acid lysine is symbolized as

(a) K

(b) R

(d) H

183. Which of the following residue in DNA exists predominantly as the keto tautomer?

(a) Cytosine

(b) Guanine

(d) Thymidine

184. D-galactose upon reduction gives

(a) D-sorbitol

(b) D-Ribitol

(c) D-Dulcitol

(d) D-Mnnitol

185. Glycoprotein laminin functions as

(a) Transporter

(b) Blood clotting

(d) Cell recognition and adhesion

186. What is the common name of cis-9-octadecanoic acid?

(a) Oleic acid (b) Linoleic acid

187. For vitamin D1

(a) 1 IU is contained in 7 6mg of standard preparation

(b) 1 lU is present in 0.344 µg of standard preparation

(c) 1 IU is contained in 0.025 µg of standard preparation

(d) 1 lU is present in 7 µg of standard preparation

188. Tyrosine gives the entire test positive except _______

(a) Xanthoprotic reaction

(b) Folin-Coicalteau’s test

(d) Hopkins-Cole reaction

189. Which of the following test is specific for the ketone bodies?

(a) Rothera’s test

(b) Gammelin’s test

(c)Hay’s test

(d) Fouchet’s test

190. Which of the following tests are positive for bile salts?

(a) Hay’s test

(b) Patternkofer’s test

(c) Both (a) and (b)

(d) None of the above

191. Which method is used for blood glucose estimation?

(a) Alkaline picrate method

(b) Diacyl monoxime method

(c) Folin Wu method

(d) Bromocresol green dye method

192. Which of the following does not cause haemolysis in GP6D?

(a) Primaquine

(b) Sulfonamide

(d) Penicillin

193. Which of the following conjugations is not done by

microsomal enzyme?

(a) Sulfate conjugation

(b) Gultathione conjugation

(d) Glucuronidation

194. Which vitamin deficiency causes cheilosis?

(a) Thiamine (b) Riboflavin

195. Which of the following tests is specific for ketohexoses?

(a) Molisch test

(b) Benedict’s test

(d) Seliwanoff’s test

196. Hopkins-Cole reaction is for which type of amino acid?

(a) Aromatic amino acid

(b) Imidazole ring

(d) None of the above

197. The following protein/ polypeptide has a quaternary

structure.

(a) Chymotrypsin

(b) Haemoglobin

(d) Myoglobin

198. Maltose is composed by

(a) Glucose + Galactose

(b) Fructose + Galactose

(d) Glucose + Glucose

199. Protein X is formed by two chains with 80 amino acids in

one chain and 58 in the other. These two chains are linked by disulfide bonds and all the essential amino acids are present in the structure, but not all the non-essential amino

acids. With this information, we can say that this protein is:

(a) A globular protein

(b) A fibrous protein

(d) A complete protein

200. An amino acid that yields acetoacetyl CoA during the catabolism of its carbon skeleton would be considered:

(a) Glycogenic

(b) Ketogenic

(d) Neither glycogenic nor ketogenic

201. The NH3 produced in muscle degradation of nitrogenated compounds is transported through blood to the liver using ______ as carriers.

(a) Alanine and glutamine

(b) Urea and alanine

(d) Glutamate and glutamine

202. Nitric oxide and urea have in common __________ as an immediate precursoramino acid.

(a) Aspartate (b) Arginine

203. The correct conformation of complex proteins is achieved with the help of

(a) Chaperones

(b) Hing domain

(d) None of the above

204. Which of the following immunoglobulins has B-cell

receptor as major function?

(a) IgA

(b) IgE

(c) IgD

(d) IgG

205. What is the starting material of biotin?

(a) Bisbenzyl succinic acid

(b) Ribulose

(d) Beta -ionone and methyl lactone

206. What is the starting material of ascorbic acid?

(a) Beta -ionone and methyl lactone

(b) Benzaldehyde and isobutraldehyde

(c) Ribose

(d) Ribulose

207. Which of the following occurs due to defect in uroporphyrinogen decarboxylase?

(a) Protoporphyria

(b) Hereditary coporphyria

(c) Porphyria cutaneatarda

(d) Acute intermittant porphyria

208. The P:O ratio for oxidation of FADH2 is?

(a) 1 (b) 2

209. Which of the following is the sulfur-containing compound involved in decarboxylation reaction?

(a) Choline (b) Lipoic acid

210. Which one is described as “vitamin in search of disease”?

(a) Vitamin A (b) Vitamin C

(c) Vitamin E (d) Vitamin H

211. Wernicke–Korsakoff syndrome is due to deficiency of vitamin?

(a) B1 (b) Riboflavin

212. Which vitamin decreases circulatory free fatty acid in adipose tissue?

(a) Riboflavin (b) Ascorbic acid

213. Which vitamin is only synthesized by microorganism

and not by plant or animal?

(a) Riboflavin (b) Ascorbic acid

214. The reaction given by two or more peptide linkages is?

(a) Biuret test

(b) Ninhydrin test

(d) Pauley’s test

215. How many base pairs are present in each turn of β-form of DNA helix?

(a) 9 (b) 10

216. Which of the following is the inhibitor of isocitrate dehydrogenase in Krebs cycle?

(a) ATP (b) AMP

217. In muscular dystrophy serum level of which enzyme is elevated?

(a) Acid phosphatase

(b) Creatinine phosphokinase

(d) Aldolase

218. In Wilson’s disease serum level of which enzyme decreases?

(a) Amylase

(b) Ceruloplasmin

(c) Glucose-6-phosphate dehydrogenase

(d) Creatine phosphokinase

219. In visual cycle, iodopsin gives which pigment?

(a) Red

(b) Green

(d) Blue

220. Caprylic acid chemically is

(a) CH3[CH2]4COOH

(b) CH3[CH2]6COOH

(d) CH3[CH2]10COOH

MCQs - Biochemistry part 2

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